Publication detail

The Synthesis, Surface Modification and Stability of SPIO Nanoparticles for MRI Application

KOVÁŘ, D. FOHLEROVÁ, Z. MALÁ, A. JIŘÍK, R. STARČUK, Z. KALINA, M. SKLÁDAL, P.

Original Title

The Synthesis, Surface Modification and Stability of SPIO Nanoparticles for MRI Application

Type

abstract

Language

English

Original Abstract

The biocompatibility and biodegradability of new magnetic resonance imaging (MRI) contrast agents is high-ly desired. The superparamagnetic iron oxide (SPIO) nanoparticles are suitable candidates for these pur-poses. Here the co-precipitation technique for synthesis of monodispersed SPIO nanoparticles is pre-sented. The critical point of the synthesis is core formation and consequent crystal growth. The conditions for core formation (time, temperature, rate of base addition) were optimised. The nanoparticles were stabilised by either silanisation or polymer coating (cationic chitosan, poly-D-Arg, dextran, gelatine, hyaluronic acid). The stability was investigated in physiological pH, different ionic strength solutions, PBS-albumine solution or blood plasma. The biocompatibility was tested in vitro either in the presence of Saccharomyces cerevisiae or erythrocytes suspension. The size and shape was investigated by atomic force microscopy (AFM) and scanning electron microscopy (SEM). The molecular structures of nanoparticles were investigated by FTIR (Fourier transform infrared spectroscopy). The iron cations were determined using the Prussian blue staining test. The stability of nano-particles was investigated by the zeta potential using the method of electrophoretic light scattering (ELS).

Keywords

nanoparticles, surface modification, stability, particle size, particle shape, structure

Authors

KOVÁŘ, D.; FOHLEROVÁ, Z.; MALÁ, A.; JIŘÍK, R.; STARČUK, Z.; KALINA, M.; SKLÁDAL, P.

Released

16. 10. 2013

Publisher

TANGER Ltd.

Location

Brno

ISBN

978-80-87294-44-4

Book

Nanocon 2013 - Conference proceedings

Edition

1

Edition number

1

Pages from

113

Pages to

113

Pages count

1

BibTex

@misc{BUT102737,
  author="David {Kovář} and Zdenka {Fohlerová} and Aneta {Malá} and Radovan {Jiřík} and Zenon {Starčuk} and Michal {Kalina} and Petr {Skládal}",
  title="The Synthesis, Surface Modification and Stability of SPIO Nanoparticles for MRI Application",
  booktitle="Nanocon 2013 - Conference proceedings",
  year="2013",
  series="1",
  edition="1",
  pages="113--113",
  publisher="TANGER Ltd.",
  address="Brno",
  isbn="978-80-87294-44-4",
  note="abstract"
}