Publication detail

From Na+/K+-ATPase and Cardiac Glycosides to Cytotoxicity and Cancer Treatment

BABULA, P. MASAŘÍK, M. ADAM, V. PROVAZNÍK, I. KIZEK, R.

Original Title

From Na+/K+-ATPase and Cardiac Glycosides to Cytotoxicity and Cancer Treatment

Type

journal article in Web of Science

Language

English

Original Abstract

The cardiac glycosides are a group of compounds isolated from plants and some animals. They have been used in therapy for heart failure for many years. The cytotoxic effect of many cardiac glycosides has been demonstrated, but the mechanism of action is very complicated and complex, and Na+/K+-ATPase surely plays a crucial role in it. On the other hand, Na+/K+-ATPase is regulated by many endogenous factors, such as hormones or FXYD proteins, whose role in regulating the cell cycle has been studied intensively. This review focuses on the role of Na+/K+-ATPase in regulating the cell growth, the cell cycle and the cell proliferation and on the involvement of cardiac glycosides in regulating Na+/K+-ATPase. The cytotoxic effect of cardiac glycosides is discussed with respect to the apoptotic mechanisms possibly induced by these compounds. Novel strategies in cancer therapy based on cardiac glycosides are discussed as are possibilities for counteracting multidrug resistance by using cardiac glycosides. The aim of this review is to present cardiac glycosides not only as pharmaceuticals used in the management of heart failure, but also as potent cytotoxic agents with potential uses in cancer treatment.

Keywords

Cardiac glycosides; apoptosis; cancer; Na+/K+-ATPase; FXYD proteins; cytostatics

Authors

BABULA, P.; MASAŘÍK, M.; ADAM, V.; PROVAZNÍK, I.; KIZEK, R.

RIV year

2013

Released

1. 9. 2013

Publisher

Bentham Science Publishers

ISBN

1871-5206

Periodical

Anti-Cancer Agents in Medicinal Chemistry

Year of study

13

Number

7

State

United Arab Emirates

Pages from

1069

Pages to

1087

Pages count

18

URL

http://www.ingentaconnect.com/content/ben/acamc/2013/00000013/00000007/art00013

BibTex

@article{BUT101916,
  author="Petr {Babula} and Michal {Masařík} and Vojtěch {Adam} and Valentine {Provazník} and René {Kizek}",
  title="From Na+/K+-ATPase and Cardiac Glycosides to Cytotoxicity and Cancer Treatment",
  journal="Anti-Cancer Agents in Medicinal Chemistry",
  year="2013",
  volume="13",
  number="7",
  pages="1069--1087",
  issn="1871-5206",
  url="http://www.ingentaconnect.com/content/ben/acamc/2013/00000013/00000007/art00013"
}